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Jafari, S., Maleki Dizaj, S
We note that MR-Egger regression has lower statistical power compared to other methods (e.g., IVW) due to its reliance on the Instrument Strength Independent of Direct Effect (InSIDE) assumption and its sensitivity to weak instruments
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Moreover, pricing pressures and reimbursement challenges from healthcare systems, particularly in developing countries, make it difficult to ensure equitable access
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